What We Do
The Lyssiotis lab uses a multi-disciplinary approach encompassing methods in chemistry and biology to define how metabolism is rewired in cancer. This work spans the areas of cancer metabolism, the tumor microenvironment and immunometabolism using and developing protocols in mass spectrometry-based metabolomics. Ultimately, we aim to transition new information about these processes into targeted therapies for cancer and other diseases. Please explore our website for more information and follow updates and lab happenings on Twitter (@LyssiotisLab).
Featured Publications
News & Announcements
A new paper published in Cell Metabolism
When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade, by Mengrou Shan and Costas A. Lyssiotis published in Cell Metabolism on 5 December 2017. Link
Scientists Discover Surprising Immune Cell Activity That May Limit Immunotherapy
Suppressive Treg cells become even more suppressive when they die, a new study finds. Researchers have uncovered a surprising process within a key immune cell that may help explain the limitations of immunotherapy as a cancer treatment. Regulatory T cells, or Treg...
New paper published in PNAS
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers, by Bollong MJ et al. published in Proc Natl Acad Sci U S A on Oct 30, 2017. Link