Cancer Biochemistry and Immune Metabolism Laboratory at the University of Michigan Medical School and Rogel Cancer Center
What We Do
The Lyssiotis lab uses a multi-disciplinary approach encompassing methods in chemistry and biology to define how metabolism is rewired in cancer. This work spans the areas of cancer metabolism, the tumor microenvironment and immunometabolism using and developing protocols in mass spectrometry-based metabolomics. Ultimately, we aim to transition new information about these processes into targeted therapies for cancer and other diseases. Please explore our website for more information and follow updates and lab happenings on Twitter (@LyssiotisLab).
News & Announcements
When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade, by Mengrou Shan and Costas A. Lyssiotis published in Cell Metabolism on 5 December 2017. Link
Suppressive Treg cells become even more suppressive when they die, a new study finds. Researchers have uncovered a surprising process within a key immune cell that may help explain the limitations of immunotherapy as a cancer treatment. Regulatory T cells, or Treg...
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers, by Bollong MJ et al. published in Proc Natl Acad Sci U S A on Oct 30, 2017. Link