Grant Support

Current

R01 A248160 (04/2020 – 03/2025)
National Cancer Institute
Stromal Metaolism Promotes Therapeutic resistance in Pancreatic Cancer
Role: Principal Investigator

ASPIRE AWARD (11/2019 – 011/2020)
Mark Foundation
Malic Enzyme Dependence is a Therapeutic Vulnerability in Pancreatic Cancer
Role: Principal Investigator

INNOVATION AWARD (10/2019 – 09/2021)
Alex’s Lemonade Stand
Therapeutic Targeting of the Disrupted Metabolic State in DIPG
Role: Principal Investigator

R01 (07/2020 – 06/2025)
National Cancer Institute
Metabolic impact on T-cell mediated cancer immunity and therapy
Role: co-Investigator (with Zou)

R01 HL 144657-01 (09/2018 – 08/2023)
National Institutes of Health
Computational systems analysis of cardiac mechanical0energetic coupling in heart disease
Role: Collaborator (PI: Beard)

2RO1 GM101171-06 (08/2018 – 04/2022)
National Institutes of Health
Regulation of one carbon metabolism and epigenetics by SIRT5
Role: co-Investigator (with Lombard)

R01 CA218139 (09/2017 – 08/2022)
National Institutes of Health, sub-contract MD Anderson Cancer Center
Medium-Chain Acyl-Coenzyme A Dehydrogenase as an Essentaial Feeder of Glioblastoma
Role: co-Investigator (with Draetta)

R21 (12/2019 – 11/2021)
National Institute on Deafness and Other Communication Disorders
Metabolomics and Lipidomics of Noise Induced Hearing Loss
Role: co-Investigator (with Corfas)

R37 CA237421 (12/2019 – 11/2026)
National Cancer Institute
Intratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic Cancer
Role: Principal Investigator

R01 CA244931 (08/2020 – 11/2025)
National Cancer Institute
Targeting Metabolic Stress in Pancreatic Cancer
Role: Principal Investigator

Application and Core Technology University Research Grant (01/2020 – 12/2020)
Agilent
Defining Nutrient Inputs that Fuel Pancreatic Tumor Metabolism in Vivo Using Stable-Isotope Tracing Metabolomics
Role: Principal Investigator

NextGen Young Investigator Award (07/2017 – 06/2020)
American Association for Cancer Research
Intratumoral Metabolic Crosstalk Supports Pancreatic Tumor Growth
Role: Principal Investigator

R01 (07/2019– 06/2024)
National Cancer Center
Unraveling metabolic dependencies in H3K27M mutant Diffuse Intrinsic Pontine Gliomas
Role: co-Investigator (PI: Venneti)

R01 CA218116 (09/2018– 06/2023)
National Institutes of Health, sub-contract University of Washington
Investigations of menin function in Ewing sarcoma
Role: co-Investigator (PI: Lawlor)

U01-CA218139 (09/2017– 06/2020)
National Institutes of Health
Interrupting Cellular Crosstalk in the Immunosuppressive Microenvironment of Pancreas Cancer
Role: co-Investigator (with Crawford & Pasca di Magliano)

R01 CA215607  (03/2017– 02/2022)
National Institutes of Health / Columbia University
Targeting cystine import to induce ferroptotic cell death in pancreatic cancer
Role: co-Investigator (PI: Olive)

 

Completed

FORBES (03/2019 – 02/2020)
Forbes Institute for Cacner Discovery, University of Michigan
Mapping Metabolic Rewiring in Brain Tumors In Vivo
Role: co-Principal Investigator (with Wahl)

PEDIATRIC BRAIN TUMOR INITIATIVE (01/2019 – 12/2020)
Universty of Michigan, Department of Pediatrics
Priming DIPG for immunogenic cell death by inducing ferroptosis
Role: Principal Investigator

RESEARCH SCHOLAR GRANT (01/2019 – 12/2019)
American Cancer Society
Intratumoral metabolic crosstalk mechanisms in pancreatic cancer
Role: Principal Investigator

PEDIATRIC BRAIN TUMOR INITIATIVE (04/2018 – 03/2019)
University of Michigan, Department of Pediatrics
Targeting metabolic reprogramming in H3K27M DIPGs
Role: co-Principal Investigator (with Venneti)

V FOUNDATION SCHOLAR AWARD  (11/2016 – 11/2018)
The V Foundation
Defining and Targeting Intra-tumoral Metabolite Transfer in Pancreatic Cancer
Role: Principal Investigator

PATHWAY TO LEADERSHIP AWARD  (07/2013 – 06/2018)
Pancreatic Cacner Action Network/American Association for Cancer Research
Exploration and Targeting of Metabolic Dependencies in Pancreatic Cancer
Role: Principal Investigator

LEFKOFSKY FAMILY FOUNDATION SCHOLAR AWARD (02/2016 – 06/2018)
Lefkofsky Family Foundation
Defining and Exploiting Metabolic Dependencies in Pancreatic Cancer
Role: Principal Investigator

EBS INNOVATION INITIATIVE (09/2017 – 08/2018)
University of Michigan Endowment for the Basic Sciences
Targeting of Micronutrient Dependenc in Colon Cancer
Role: co-Principal Investigator (with Shah)

CANCER CENTER RESEARCH COMMITTEE RESEARCH GRANT (02/2017 – 01/2018)
University of Michigan Comprehensive Cancer Cancer
Role and Mechanism of Serine Synthesis Pathway Activation in Ewing Sarcoma
Role: co-Principal Investigator (with Lawlor)

P30 CANCER CENTER SUPPORT GRANT SUPPLEMENT (08/2016 – 07/2017)
National Cancer Institute
Therapeutic Modulation of the Immune Microenvironment in Pancreatic Cancer
Role: co-Principal Investigator (with Lawrence, Crawford, Pasca di Magliano, Simeone)

DALE F. FREY AWARD FOR BREAKTHROUGH SCIENTISTS (10/2015 – 09/2017)
Damon Runyon Cancer Research Foundation
Exploration and Targeting of Metabolic Dependencies in Pancreatic Cancer
Role: Principal Investigator

DEPARTMENT OF DEFENSE CANCER DISCOVERY GRANT (10/2012 – 09/2014)
In vivo Measurement of Oncogenic Kras-Dependent Glucose Metabolism in Mouse Models of Pancreatic Cancer
Role: co-Principal Investigator (with Kimmelman and Ying)

DAMON RUNYON POSTDOCTORAL FELLOWSHIP (10/2010 – 05/2013)
Exploring the Metabolic Effects of Oncogenic Kras in Pancreatic Ductal Adenocarcinoma
Role: Principal Investigator

ROGEL CANCER CENTER P01 DEVELOPMENT GRANT (06/2018 – 05/2020)
University of Michigan, Rogel Cancer Center
Cellular Cross-talk in the Pancreatic Cancer Microenvironment 
Role: co-Principal Investigator (with Crawford, Pasca, Lawrence, Zou, Frankel, & Morgan)

APPLICATIONS AND CORE TECHNOLOGY UNIVERSITY RESEARCH GRANT (06/2018 – 05/2019)
Agilent
Deciphering Metabolic Networks in the Pancreatic Tumor Microenvironment with Seahorse Analysis and Stable Isotope Tracing
Role: Principal Investigator

ROGEL CANCER CENTER GRANT (11/2018 – 10/2019)
University of Michigan, Rogel Cancer Center
Malic Enzyme Isoform Dependencies Reveal Therapeutic Vulnerabilities in Pancreatic Cancer
Role: Principal Investigator

TEAM SCIENCE AWARD (06/2018 – 05/2019)
Melanoma Reserach Alliance
Targeting Mitochondrial Metabolism in Melanoma Therapy
Role: co-Principal Investigator (with Lombard, Neamati, & Kennedy)

PEDIATRIC BRAIN TUMOR INITIATIVE (04/2018 – 03/2019)
University of Michigan, Department of Pediatrics
Therapeutic Targeting of the Disrupted Metabolic State in DIPG to Induce Ferroptotic Cell Death
Role: Principal Investigator

PEDIATRIC BRAIN TUMOR INITIATIVE  (03/2017 – 02/2018)
University of Michigan, Department of Pediatrics
Metabolic Approaches to Combat DIPG
Role: cco-Principal Investigator (with Venneti)

AUGUSTYN AWARD IN DIGESTIVE CANCER (07/2016 – 06/2017)
American Gastroenterological Association
Non-tumorigenic Support Cells Fuel Pancreatic Cancer Metabolism
Role: Principal Investigator

RESEARCH GRANT (07/2016 – 06/2017)
St. Baldricks
Targeting mitochondrial metabolism in Ewing sarcoma
Role: co-Principal Investigator (with Lombard, Lawlor)

M-CUBED (11/2015 – 04/2017)
Harnessing T Cell Metabolism for Immunotherapy
Role: co-Principal Investigator (with Glick and Opipari)

RESEARCH GRANT (07/2016 – 06/2017)
National Pancreas Foundation
Non-tumorigenic Support Cells Fuel Pancreatic Cancer Metabolism
Role: Principal Investigator

INNOVATION AND DISCOVERY GRANT (07/2016 – 06/2017)
American Association of Cancer Research – Bayer
Development of Small Molecule Inhibitors of the Pancreatic Cancer-Specific Enzyme GOT1
Role: Principal Investigator

KIMMEL SCHOLAR AWARD (07/2016 – 06/2018)
Sidney Kimmel Cancer Research Foundation
Defining and Targeting Metabolic Dependencies in Pancreatic Cancer
Role: Principal Investigator

RESEARCH GRANT (01/2013 – 12/2015)
Lustgarten Foundation
Development of Small Molecule Inhibitors of Pancreatic Cancer Metabolism
Role: Consultant (Principal Investigators: Kimmelman, Cantley, Lairson)