Reviews & Commentaries

Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer.
Halbrook CJ, Wahl DW, Lyssiotis CA. Trends in Biochemical Sciences (2019) 44:991–993
Abstract PDF

The Metabolic Regulation of Redox Balance in Cancer.
Purohit V, Simeone D, Lyssiotis CA. Cancers (2019) 11:7.
Abstract PDF

New tricks for an old drug.
Nelson BS, Kremer DM, Lyssiotis CANat Chem Biol (2018) [Epub ahead of print].
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Metabolism and Epigenetics of Pancreatic Cancer Stem Cells
Perusina Lanfranca M, Thompson JK, Bednar F, Halbrook C, Lyssiotis C, Levi B, Frankel TL. Semin Cancer Biol (2018) [Epub ahead of print].
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The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
Abbruzzese JL, Andersen DK, Borrebaeck CAK, Chari ST, Costello E, Cruz-Monserrate Z, Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA, Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC. Pancreas (2018) 47:516-525.
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Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation
Halbrook CJ, Nwosu ZC, Lyssiotis CATrends Endocrinol Metab (2018) 29:599-602.
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Tumor Crosstalk Networks Promote Growth and Support Immune Evasion in Pancreatic Cancer

Halbrook CJ, Pasca di Magliano M, Lyssiotis CAAm J Physiol Gastrointest Liver Physiol (2018) 315:G27-G35.
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When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade 
Shan M, Lyssiotis CACell Metabolism (2017) 26:811–813.
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A Topical Report on the Design Principles of Metabolism
Halbrook CJ, Lee HJ, Cantley LC, Lyssiotis CA. Imaging and Metabolism, Springer, Cham, (2018) 29-44.
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Metabolic Interactions in the Tumor Microenvironment

Lyssiotis CA, Kimmelman AC. Trends in Cell Biology (2017) 27:863-875.
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Emerging roles for SIRT5 in metabolism and cancer
Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB. Antioxid Redox Signal. (2017) 28:677-90.
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Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Halbrook CJ, Lyssiotis CACancer Cell (2017) 31:5-19.
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Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant Kras-Driven Cancers
Shah Y, Lyssiotis CAGastroenterology (2016) 151:798-801.
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A Novel Small-Molecule Inhibitor of 3-Phosphoglycerate Dehydrogenase
Mullarky E, Lairson LL, Cantley LC, Lyssiotis CAMolecular and Cellular Oncology (2016) 3:e1164280.
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Metabolic Reprogramming by the PI3K/AKT-mTOR Pathway in Cancer
Lien E, Lyssiotis CA, Cantley LC. In: Recent Results in Cancer Research. Metabolism in Cancer. New York, NY. Springer Publishing Group. Kramer T, Schmitt CA. eds. (2016) 207:39–72.
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Designing a Broad-Spectrum Integrative Approach for Cancer Prevention and Treatment
Getting to Know Cancer Taskforce*. [*member of >200 author taskforce] Seminars in Cancer Biology (2015) 35S, S276–S304.
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Dysregulated Metabolism Contributes to Oncogenesis
Hirschey MD, *DeBerardinis RJ, *Diehl AME, *Drew J, *Frezza C, *Green MF, *Jones LW, *Ko YH, *Le A, *Lea MA, *Locasale JW, *Longo VD, *Lyssiotis CA, *McDonnell E, *Mehrmohamadi M, *Michelotti G, *Muralidhar V, *Murphy MP, *Pedersen P, *Poore B, *Raffaghello L, *Rathmell JC, *Sivanand S, *Vander Heiden MG, *Wellen KE; Target Validation Team. [*equal contribution; authors listed alphabetically] Semin Cancer Biol (2015) 35S, S129–S150.
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Acetate Fuels the Cancer Engine
Lyssiotis CA, Cantley LC. Cell (2014) 159, 1492–1494.
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Fluxing Through Cancer: Tracking the Fate of 13C-Labeled Energy Sources in Cancer Cells and Mouse Tumors
Lyssiotis CA, Breitkopf SB, Yuan M, Bellinger G, Asara JM. Cambridge Isotope Labs (2014) Application Note 34.

Targeting Metabolic Scavenging in Pancreatic Cancer
Lyssiotis CA, Cantley LC. Clinical Cancer Research (2014) 20, 6–8.
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Metabolic Syndrome: F Stands for Fructose and Fat
Lyssiotis CA, Cantley LC. Nature (2013) 502, 181–182.
Abstract | PDF | Press

Pancreatic Cancers Rely on a Novel Glutamine Metabolism Pathway to Maintain Redox Balance
Lyssiotis CA, Son J, Cantley LC, Kimmelman AC. Cell Cycle (2013) 12, 1987–1988.
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SIRT6 Puts Cancer Metabolism in the Driver’s Seat
Lyssiotis CA, Cantley LC. Cell (2012) 151, 1155-1156.
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Small Molecule-Based Approaches to Adult Stem Cell Therapies
Lairson LL, Lyssiotis CA, Zhu S & Schultz PG. Annual Review of Pharmacology and Toxicology (2013) 6, 107–125.
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Emerging Concepts: Linking Hypoxic Signaling and Cancer Metabolism
Lyssiotis CA, Vander Heiden MG, Muñoz-Pinedo C, Emerling BM. Cell Death and Disease (2012) 3, e303.
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Cellular Control Mechanisms that Regulate Pyruvate Kinase M2 Activity and Promote Cancer Growth
Lyssiotis CA, Anastasiou D, Locasale JW, Vander Heiden MG, Christofk HR, Cantley LC. Biomed Research (2012) 23, 213–217.

Chemical Control of Stem Cell Fate and Developmental Potential
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Angewandte Chemie (2011) 50, 200–242.
Abstract | PDF | German | Times cited: 83

Insight into the Reprogramming of Cell Fate with Small Molecules
Lyssiotis CAGraduate Thesis (2010).
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Reprogramming Developmental Potential
Lyssiotis CA, Charette BD & Lairson LL. In: Emerging Technology Platforms for Stem Cells (2009) New York, NY. John Wiley & Sons Press, Inc.; 51–85. Lakshmipathy U, Chesnut JD & Thyagarajan B, eds.
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Cautiously Interpret Data
Lyssiotis CAChemical & Engineering News (2007) Nov-12, 6.