Research Activities

Click Here for a list of all publications

Highlighted in Cancer Discovery 2020;10:345–7.

Regulatory T cell depletion causes compensatory immune suppression and accelerated pancreatic carcinogenesis.
Abstract | PDF

Highlighted in Cancer Discovery 2020;10(6):757.

Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Abstract | PDF

Highlighted in Gut Microbes 2020;18:1-3.

A Ribose-Scavenging System Confers Colonization Fitness on the Human Gut Symbiont Bacteroides thetaiotaomicron in a Diet-Specific Manner.
Abstract | PDF

 

 

Highlighted in Nature Reviews Nephrology 2019; ePub ahead of print.

Abnormal oxidative metabolism in a quiet genomic backgorund underlies clear cell papillary renal cell carcinoma.
Abstract | Full Article

Highlighted in Nature Reviews Cancer 2019;19:304.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF

 

Highlighted in Nature Reviews Immunology 2019;19:202-203

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF

 

Highlighted in Science Translational Medicine 2019;11:487.

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF

 

Highlighted in Cancer Discovery 2019;9:574

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF

 

Highlighted in Nature Reviews Gastroenterology & Hepatology 2019;16:262

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Abstract | PDF

 

Highlighted in JBC Special (Virtual) Issue on Tumor Metabolism

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.
Abstract | PDF

Highlighted in Cell Metabolism (2017). Apoptotic Regulatory T Cells Retain Suppressive Function Through Adenosine

Oxidative Stress Controls Regulatory T cell Apoptosis and Suppressor Activity and PD-L1-blockade Resistance in Tumor
Abstract | PDF

Highlighted in Cancer Cell (2017). MUC-king with HIF May Rewire Pyrimidine Biosynthesis and Curb Gemcitabine Resistance in Pancreatic Cancer

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Abstract | PDF

Highlighted in Pancreatic Cancer Action Network (2017). Grantees Collaborate to Understand Treatment Resistance

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Abstract | PDF

Highlighted in Nature (2016). Cancer metabolism: Friendly neighbours feed tumour cells 

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information

Highlighted in Science Signaling (2016). PDAC puts its neighbors to work | Article

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information

Highlighted in Nature Reviews Cancer (2016). Feeding your friends

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information

Highlighted in Nature Reviews Gastroenterology & Hepatology (2016). Pancreatic cancer: Stromal crosstalk supports tumour metabolism

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information

Highlighted in Cancer Discovery (2016). Autophagic Pancreatic Stellate Cells Promote Pancreatic Tumour growth

Pancreatic Stellate Cells Support Tumour Metabolism Through Autophagic Alanine Secretion
Abstract | PDF | Supplementary Information

Highlighted by Science Daily. Team Finds New Approach to Curbing Cancer Growth

Identification of a Small Molecule Inhibitor of 3-Phosphoglycerate Dehydrogenase to Target Serine Biosynthesis in Cancers
Abstract | PDF

 

Highlighted in Cancer Discovery. PI3K Promotes Glycolysis through Release of Cytoskeletal Aldolase

Phosphoinositide 3-Kinase Regulates Glycolysis Through an AKT-independent Mechanism that Mobilizes Aldolase A Release from the Actin Cytoskeleton
Abstract | PDF

Most read paper in Cancer & Metabolism, 2015.

Targeting Glutamine Metabolism Sensitizes Pancreatic Cancer to PARP1-driven Metabolic Catastrophe Induced by ß-lapachone
Abstract | PDF

U.S. Patent Number 2015/0126580, filed December 20, 2011 and issued May 7, 2015.

Methods for Diagnosing and Treating Oncogenic Kras-Associated Cancer. 
DePinho R, Cantley LC, Kimmelman A, Ying H, Lyssiotis CA. International Patent Number 14/367,341, filed June 20, 2014.

U.S. Patent Number 2015/0110773, filed May 23, 2013 and issued April 23, 2015.

Targeting the Glutamine to Pyruvate Pathway for Treatment of Oncogenic Kras-Associated Cancer.    Kimmelman AC, Son J, Cantley LC, Lyssiotis CA.

Highlighted in Nature Reviews Clinical Oncology (2014). Targeting Mitochondria in Pancreatic Cancer

Oncogene Ablation-Resistant Pancreatic Cancer Cells Depend on Mitochondrial Function
Abstract | PDF | Extended Figures | Times cited: 164

Highlighted in Cancer Discovery (2014). Resistant PDAC Cells Require Mitochondrial Activity

Oncogene Ablation-Resistant Pancreatic Cancer Cells Depend on Mitochondrial Function
Abstract | PDF | Extended Figures | Times cited: 164

Highlighted by MDACC. Researchers Discover a Metabolic Mechanism for Resistant Pancreatic Cancer

Oncogene Ablation-Resistant Pancreatic Cancer Cells Depend on Mitochondrial Function
Abstract | PDF | Extended Figures | Times cited: 164

International Patent Number WO2014080381 A1, filed November 26, 2013 and issued May 30, 2014.

Colorectal Cancer Classification with Differential Prognosis and Personalized Therapeutic Responses
Hanahan D, Gray J, Sadanandam A, Lyssiotis CA. 
Patent

Selected as the best science paper in MS in 2013. Multiple Sclerosis (2014)

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

Highlighted by The Gaurdian. Parkinson’s Drug Could Prove to be New Treatment for Multiple Sclerosis

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

h

Highlighted by U~T San Diego. Parkinson’s Drug Holds Promise for MS

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

Highlighted by TSRI. New Strategy to Treat Multiple Sclerosis Shows Promise in Mice

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

Highlighted in Nature Reviews Drug Discovery (2013). Parkinson’s Drug Promotes Myelin Repair

 

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

Highlighted in Nature Reviews Neurology (2013). Drug-enhanced Remyelination in a Multiple Sclerosis Model

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

Highlighted in Nature Chemical Biology (2013). Reversing MS 

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

Highlighted in Nature (2013). An Old Drug Plays a New Trick 

A Regenerative Approach to the Treatment of Multiple Sclerosis
Abstract | PDF | Extended Figures | Supporting Information | Times cited: 121

International Patent Number WO/2012/112933, filed February 17, 2012 and issued February 6, 2014.

Directed Differentiation of Oligodendrocytes Precursor Cells into a Myelinating Cell Fate
Deshmukh V, Lyssiotis CA, Lairson LL, Schultz PG.

Highlighted in Nature Reviews Cancer (2013). Colorectal Cancer Classifications | PDF

A Colorectal Cancer Classification System that Associates Cellular Phenotype and Responses to Therapy
Abstract | PDF | Supporting Information | Times cited: 291

Highlighted in Nature Reviews Clinical Oncology (2013). Turning Up Trumps for New CRC Subtypes

A Colorectal Cancer Classification System that Associates Cellular Phenotype and Responses to Therapy
Abstract | PDF | Supporting Information | Times cited: 291

Highlighted in Nautre Biotechnology (2013). Cancer Metabolism in Breadth and Depth

Glutamine Supports Pancreatic Cancer Growth Through a KRAS-Regulated Metabolic Pathway
Abstract | PDF | Supporting Information | Times cited: 367

Highlighted in Nature Reviews Cancer (2013). Glutamine Connections to Oncogene Alterations 

Glutamine Supports Pancreatic Cancer Growth Through a KRAS-Regulated Metabolic Pathway
Abstract | PDF | Supporting Information | Times cited: 367

Highlighted in Cancer Discovery (2013). KRAS Reprograms Glutamine Metabolism in Pancreatic Cancer

Glutamine Supports Pancreatic Cancer Growth Through a KRAS-Regulated Metabolic Pathway
Abstract | PDF | Supporting Information | Times cited: 367

Highlighted in Nature Reviews Gastroenterology and Hepatology (2013). Novel Pathway Identified for glutamine metabolism in PDAC

Glutamine Supports Pancreatic Cancer Growth Through a KRAS-Regulated Metabolic Pathway
Abstract | PDF | Supporting Information | Times cited: 367

Highlighted by Dana Farber. Scientists Find Potential Loophole in Pancreatic Cancer Defenses

Glutamine Supports Pancreatic Cancer Growth Through a KRAS-Regulated Metabolic Pathway
Abstract | PDF | Supporting Information | Times cited: 367

Highlighted in Nature Reviews Cancer (2012). Metabolism: Nuclear Functions

ERK1/2-Dependent Phosphorylation and Nuclear Translocation of PKM2 Promotes the Warburg Effect
Abstract | PDF | Supporting Information

Highlighted by Science Daily. Metabolic Protein Launches Sugar Feast That Nurtures Brain Tumors | Article

ERK1/2-Dependent Phosphorylation and Nuclear Translocation of PKM2 Promotes the Warburg Effect
Abstract | PDF | Supporting Information

Highlighted in Science (2012). When Metabolism and Epigenetics Converge 

Influence of Threonine Metabolism on S-Adenosyl-Methionine and Histone Methylation
Abstract | PDF | Supporting Information | Times cited: 183

Highlighted in Nature Reviews Cancer (2012). Therapeutics: PI3K–PARP Combination | PDF

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1–Related Breast Cancer
Abstract | PDF | Supporting Information | Times cited: 147

Highlighted in Cancer Discovery (2012). Combining Inhibition of PI3K and PARP as Cancer Therapy | PDF

Highlighted in Cancer Discovery (2012). Combining Inhibition of PI3K and PARP as Cancer Therapy 

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1–Related Breast Cancer
Abstract | PDF | Supporting Information | Times cited: 147

Cell 20-most read articles, May 2012 Exceptional article [12], as evaluated by Faculty of 1000 

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Abstract | PDF | Supporting Information | Times cited: 454

 

Highlighted in Nature Reviews Clinical Oncology (2012). Mouse Models Link Metabolism Deubiquitination with KRAS

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Abstract | PDF | Supporting Information | Times cited: 454

Highlighted in Cancer Research (2012). Metabolic Pathways Controlling KRAS-driven Pancreatic Cancer 

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Abstract | PDF | Supporting Information | Times cited: 454

Highlighted in Science Business eXchange (2012). Kras in Cancer Metabolism

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Abstract | PDF | Supporting Information | Times cited: 454

Highlighted by MD Anderson. Mutant Kras Drives Pancreatic Cancer Maintenance via Metabolic Pathways

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Abstract | PDF | Supporting Information | Times cited: 454

Highlighted by Dana Farber. Advanced Pancreatic Tumors Depend on Continued Oncogene Activity

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Abstract | PDF | Supporting Information | Times cited: 454

Highlighted in Nature Reviews Molecular Cell Biology (2011). mTOR Targets its Own Inhibitor

mTOR Drives its Own Activation via SCFβ-TRCP-dependent Degradation of the mTOR Inhibitor DEPTOR
Abstract | PDF | Supporting Information

Highlighted by Science News Line (2012). Unraveling the Complex Signaling… 

mTOR Drives its Own Activation via SCFβ-TRCP-dependent Degradation of the mTOR Inhibitor DEPTOR
Abstract | PDF | Supporting Information

Highlighted in Nature Reviews Cancer (2011). Flexible Flux 

Phosphoglycerate Dehydrogenase Diverts Glycolytic Flux and Contributes to Oncogenesis
Abstract | PDF | Supporting Information | Times cited: 402

Highlighted in Science Business eXchange (2011). PHGDH 

Phosphoglycerate Dehydrogenase Diverts Glycolytic Flux and Contributes to Oncogenesis
Abstract | PDF | Supporting Information | Times cited: 402

Highlighted in Nature Biotechnology (2011). Spotlight on Serine Metabolism in Cancer 

Phosphoglycerate Dehydrogenase Diverts Glycolytic Flux and Contributes to Oncogenesis
Abstract | PDF | Supporting Information | Times cited: 402

Highlighted in Cell Metabolism (2011). Serine Metabolism: Some Tumors Take the Road Less Traveled

Phosphoglycerate Dehydrogenase Diverts Glycolytic Flux and Contributes to Oncogenesis
Abstract | PDF | Supporting Information | Times cited: 402

Highlighted in Pigment Cell Melanoma Research (2011). Serine biosynthesis

Phosphoglycerate Dehydrogenase Diverts Glycolytic Flux and Contributes to Oncogenesis
Abstract | PDF | Supporting Information | Times cited: 402

 

PNAS 50-most read articles, June 2009 Highlighted in Regenerative Medicine (2009)

Reprogramming of Murine Fibroblasts to iPS Cells With Chemical Complementation of Klf4
Abstract | PDF | Supporting Information | Times cited: 324

Highlighted in Nature Cell Biology (2009). Chemical iPS Cocktails 

Reprogramming of Murine Fibroblasts to iPS Cells With Chemical Complementation of Klf4
Abstract | PDF | Supporting Information | Times cited: 324

Highlighted in Assay and Drug Development Technologies (2009). Discovering Pluripotent Compounds 

Reprogramming of Murine Fibroblasts to iPS Cells With Chemical Complementation of Klf4
Abstract | PDF | Supporting Information | Times cited: 324

Highlighted in Nature Reports (2009). New Types of ES Cells Generated by Stabilizing Pluripotency 

Reprogramming of Murine Fibroblasts to iPS Cells With Chemical Complementation of Klf4
Abstract | PDF | Supporting Information | Times cited: 324

Highlighted in Nature Chemical Biology (2009). Endowing Endoderm

A Small Molecule Primes Embryonic Stem Cells for Differentiation
Abstract | PDF | Supporting Information | Times cited: 141

Highlighted in Cell Stem Cell (2009). Using Small Molecules to Great Effect in Stem Cell Differentiation

A Small Molecule Primes Embryonic Stem Cells for Differentiation
Abstract | PDF | Supporting Information | Times cited: 141

Highlighted in Molecular Interventions (2009). Stauprimide: A Small Molecule Directs Stem Cells to Differentiate

A Small Molecule Primes Embryonic Stem Cells for Differentiation
Abstract | PDF | Supporting Information | Times cited: 141

Highlighted in Cell (2007). Leading Edge: Glial Precursors Break Their Commitment 

Inhibition of Histone Deacetylase Activity Induces Developmental Plasticity in Oligodendrocyte Precursor Cells
Abstract | PDF | Supporting Information | Times cited: 92